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目的评估早期声门癌患者治疗后嗓音特征和生活质量的长期疗效。研究设计回顾性分析台湾一家医学中心的患者资料。方法 42例声门癌患者接受放疗(radiation therapy,RT)或经口激光显微手术(transoral laser microsurgery,TLM)治疗12个月后评估其嗓音和生活质量。结果 24例患者接受RT,18例患者接受TLM。两组患者无听力学和空气动力学差异,对于男性患者仅有发音基频的差异。在癌症治疗——头颈调查的功能性评估中,TLM治疗组比RT治疗组能更好地交流,但无嗓音质量和强度的差异。同样,这两组在嗓音障碍指数10(VHI-10)评估中也没有显著性差异。结论接受TLM治疗的男性患者比接受RT治疗组的男性患者,具有较高的发音基频。对于早期声门癌患者,无论是接受TLM治疗,还是接受RT治疗,嗓音相关的生活质量是相似的;但是接受TLM治疗患者具有更好的交流能力。
Objective To evaluate the long-term efficacy of voice characteristics and quality of life in patients with early stage glioma after treatment. Study Design A retrospective analysis of patient data from a medical center in Taiwan. Methods Forty-two patients with glottic cancer underwent radiation therapy (RT) or transoral laser microsurgery (TLM) for 12 months to evaluate their voice and quality of life. Twenty-four patients received RT and 18 received TLM. There was no difference in audiometry and aerodynamics between the two groups of patients, with only a difference in fundamental frequency of pronunciation for male patients. In the functional assessment of cancer treatment-head and neck surveys, the TLM-treated group was better able to communicate than the RT-treated group, but without differences in voice quality and intensity. Similarly, there was also no significant difference between the two groups in the assessment of VHI 10 (VHI-10). Conclusion Male patients receiving TLM had a higher fundamental frequency of pronunciation than male patients receiving RT. For patients with early glottic cancer, voice-related quality of life is similar for either TLM-treated or RT-treated patients; however, TLM-treated patients have better communication skills.