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目的:探究苗药双肾草水提液、醇提液对肾阳虚症小鼠主要性器官和免疫器官的影响。方法:以小鼠主要性器官睾丸、前列腺、精囊、肾脏和免疫器官胸腺、脾脏等的湿重作为测定指标,测定各指标湿重体重比指数。结果:双肾草水提组、55%醇提组、95%醇提组的体重增长率都高于模型组,低于空白对照组;水提组性器官精囊湿重体重比、睾丸湿重体重比、前列腺湿重体重比与模型组比较差异都有统计学意义,醇提各组也有不同程度的差异,免疫器官胸腺湿重、脾脏湿重体重比与模型组比较差异没有统计学意义。结论:双肾草水提液对大剂量氢化可的松所致的小鼠主要性器官萎缩有明显改善作用,对免疫器官无显著影响。
Objective: To investigate the effect of Miao medicine Shuangrencao aqueous extract and alcohol extract on the main organs and immune organs of mice with deficiency of kidney-yang. Methods: Wet weight of testis, prostate, seminal vesicles, kidneys, thymus and spleen of the main organs of mice was used as the measurement index, and the wet weight to body weight ratio index of each index was determined. Results: The body weight growth rate of Shuangrencao water group, 55% alcohol group and 95% alcohol group were higher than that of the model group, lower than that of the blank control group; Compared with the model group, the wet weight to body weight ratio of the prostate had statistical significance. The ethanol extract also had different degrees of difference in each group. There was no significant difference between the wet weight of thymus and the body weight of spleen in model group. Conclusion: Shuangrencao aqueous extract significantly ameliorates atrophy of major organs in mice induced by high-dose hydrocortisone and has no significant effect on immune organs.