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目的:通过检测巨幼细胞贫血(MA)和骨髓增生异常综合征(MDS)患者血清乳酸脱氢酶(LDH)、α-羟丁酸脱氢酶(α-HBDH)和同型半胱氨酸(Hcy)水平,探讨LDH、α-HBDH和Hcy水平高低是否对临床鉴别巨幼细胞贫血和骨髓增生异常综合征具有指导意义。方法:应用日立7600全自动生化分析仪检测36例MA和20例MDS血清中LDH、α-HBDH和Hcy水平。结果:MA组血清LDH、α-HBDH和Hcy水平明显高于MDS组,差异具有非常显著性意义(P<0.01)。结论:血清LDH、α-HBDH和Hcy水平对临床鉴别MA和MDS具有临床指导意义。
OBJECTIVE: To detect serum levels of lactate dehydrogenase (LDH), a-hydroxybutyrate dehydrogenase (a-HBDH) and homocysteine (a-HBDH) in patients with megaloblastic anemia (MA) and myelodysplastic syndrome Hcy) levels, to explore the level of LDH, α-HBDH and Hcy levels for clinical differential diagnosis of megaloblastic anemia and myelodysplastic syndromes have guiding significance. Methods: The levels of LDH, α-HBDH and Hcy in 36 MA and 20 MDS sera were detected by Hitachi 7600 automatic biochemical analyzer. Results: The levels of serum LDH, α-HBDH and Hcy in MA group were significantly higher than those in MDS group, with significant difference (P <0.01). Conclusion: Serum LDH, α-HBDH and Hcy levels have clinical significance in the differential diagnosis of MA and MDS.