高胆固醇血症(hypercholesterolemia,HC)是心血管疾病主要的独立危险因素,是动脉粥样硬化最早的病变环节之一。目前对HC损害大血管及其机制的资料丰富,认识比较深入。但对HC初期微血管、微循环的改变缺乏相关的文献资料。由于探讨HC初期微血管、微循环变化对有效防治心脑血管疾病有重要意义,因而已引起人们的 Hypercholesterolemia (HC) is the main independent risk factor of cardiovascular disease and is one of the earliest pathological changes of atherosclerosis. At present HC is rich in data on the damage of large blood vessels and their mechanisms, more in-depth understanding. But the initial HC microvascular, microcirculation changes lack of relevant literature. As the discussion of early HC microvascular, microcirculation changes for the effective prevention and treatment of cardiovascular and cerebrovascular disease is of great significance, which has caused people’s