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目的 :对两家药厂生产的阿奇霉素片及胶囊进行溶出度考察。方法 :采用硫酸显色法测定累积溶出量。结果 :阿奇霉素在 10～ 10 0 μg/ml范围内线性关系良好 ,平均回收率为 99 93% (n =6 )。阿奇霉素片及胶囊在 4 5min时的溶出量均不低于标示量的 75%。结论 :硫酸显色法操作快速简便 ,适用于阿奇霉素溶出度试验。而两厂产品体外溶出度结果均达到要求
OBJECTIVE: To investigate the dissolution rate of azithromycin tablets and capsules produced by two pharmaceutical factories. Methods: The cumulative dissolution was determined by sulfuric acid colorimetry. Results: Azithromycin showed good linearity in the range of 10 ~ 100 μg / ml with an average recovery of 99.93% (n = 6). Azithromycin tablets and capsules at 45min when the dissolution of not less than 75% of the labeled amount. Conclusion: Sulfuric acid method is quick and easy to operate and suitable for azithromycin dissolution test. The two plants in vitro dissolution results meet the requirements