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Background Studies have shown that mi RNA-155 played an important role in the process of development of hypertension.However,there is no date about mi RNA-155 and blood pressure monitoring parameters.Therefore,we examined whether in hypertensive patients the expression level of plasma mi RNA-155 related to 24-h ambulatory blood pressure monitoring(ABPM) parameters.Methods A cohort of adult patients scheduled to receive physical examination,office and ambulatory blood pressure monitoring.Quantitative reverse transcriptase polymerase chain reaction(q RT-PCR) was used to evaluate the expression of selected mi RNA-155.The mi RNA-155 expression level correlation between blood pressure parameters was assessed using the Spearman correlation coefficient.Results Fifty four essential hypertension patients(25 men;mean age,53.28 ± 9.52 years) and thirty healthy volunteers(15 men;mean age,53.03 ± 5.87 years) were included.We observed higher expression level of mi RNA-155(32.31 ± 2.85 vs 27.21 ± 1.59,P < 0.001) in hypertensive patients compared to healthy control individuals.MiRNA- 155 expression level showed significant positive correlation with 24 h Daytime SBP(r =0.681,P < 0.001),24 h Daytime DBP(r = 0.473,P < 0.001),24 h Daytime PP(r = 0.565,P < 0.001) and dipping(r = 0.257,P = 0.018),respectively.Conclusions Our study showed that mi RNA-155 expression level was associated positively with daytime blood pressure monitoring parameters,as well as blood pressure variability,indicating a possible implication of miRNA- 155 in the pathogenesis of hypertension.
Background Studies have shown that mi RNA-155 played an important role in the process of development of hypertension. Now, there is no date about mi RNA-155 and blood pressure monitoring parameters. Before, we examined whether in hypertensive patients the expression level of plasma mi RNA-155 related to 24-h ambulatory blood pressure monitoring (ABPM) parameters. Methods A cohort of adult patients scheduled to receive physical examination, office and ambulatory blood pressure monitoring. Quantitative reverse transcriptase polymerase chain reaction (q RT-PCR) was used to evaluate the expression of selected mi RNA-155. The mi RNA-155 expression level correlation between blood pressure parameters was assessed using the Spearman correlation coefficient. Results Fifty four essential hypertension patients (25 men; mean age, 53.28 ± 9.52 years ) and thirty healthy volunteers (15 men; mean age, 53.03 ± 5.87 years) were included. We observed higher expression level of mi RNA-155 (32.31 ± 2.85 vs 27.21 ± 1.59, P <0.001) in hypertensive patients compared to healthy control individuals.MiRNA-155 expression level showed significant positive correlation with 24 h Daytime SBP (r = 0.681, P <0.001) 0.001), 24 h Daytime PP (r = 0.565, P <0.001) and dipping (r = 0.257, P = 0.018), respectively.Conclusions Our study showed that mi RNA-155 expression level was associated positively with daytime blood pressure monitoring parameters , as well as blood pressure variability, indicating a possible implication of miRNA-155 in the pathogenesis of hypertension.