[目的]建立环酰菌胺在黄瓜与西葫芦中的残留分析方法。[方法]样品用乙腈匀浆提取,全自动固相萃取仪硅胶柱净化,液相色谱-串联质谱检测。[结果]黄瓜和西葫芦中的添加回收率分别为86.6%~87.2%、89.4%~90.3%,变异系数分别为3.5%~4.3%、5.2%~6.6%,仪器最小检出量为1.0×10-11g,方法最小检出质量分数为0.05 mg/kg。[结论]该方法简单可靠,符合农药残留分析要求,可用于黄瓜和西葫芦中环酰菌胺的残留检测。 [Objective] The research aimed to establish the method of residue analysis of fenhexamid in cucumber and zucchini. [Method] The samples were extracted with acetonitrile, purified by silica gel column and analyzed by liquid chromatography - tandem mass spectrometry. [Result] The recoveries of cucumber and zucchini were 86.6% ~ 87.2% and 89.4% ~ 90.3%, respectively. The coefficients of variation were 3.5% ~ 4.3% and 5.2% ~ 6.6% respectively. The minimum detectable rate was 1.0 × 10 -11g, the method detection minimum mass fraction of 0.05 mg / kg. [Conclusion] The method was simple and reliable, which met the requirements of pesticide residue analysis and could be used for the determination of fenhexamid in cucumber and zucchini.