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流行性乙型脑炎 (乙脑 )减毒活疫苗是一种安全、有效、免疫原性广的疫苗 ,其临床的保护效果得到多次观察结果证实。但乙脑活疫苗免疫持久性的观察由于工作难度大而还未见报道。为此 ,针对接种乙脑活疫苗后中和抗体持久性进行了 6年的血清学观察。结果显示 :接种疫苗前乙脑中和抗体 <1∶5的血清样本共 2 8份 ,初次免疫 1个月后中和抗体阳转率为 96 4%( 2 7/ 2 8,≥ 1∶10 )或 10 0 .0 %( 2 8/ 2 8,≥ 1∶5 ) ,加强免疫后 1个月为 10 0 0 %( 2 8/ 2 8,≥ 1∶10 ) ;加强免疫后 1年为 81 0 %( 17/ 2 1,≥ 1∶10 ) ;加强免疫后 6年抗体阳性率为 5 7 1%( 16 / 2 8,≥ 1∶10 )或75 0 %( 2 1/ 2 8,≥ 1∶5 )。表明乙脑活疫苗接种 1针 1个月后再加强免疫 1针至加强免疫后的第 6年 ,其中和抗体阳性率仍可维持在 5 7.1%～ 75 .0 %。表明乙脑活疫苗具有较好的免疫持久性。
The attenuated live Japanese encephalitis (JE) vaccine is a safe, effective and immunogenic vaccine, and its clinical protective effect has been confirmed by many observations. However, the observation of the immune persistence of JE live vaccine has not been reported due to the difficulty of work. For this reason, a 6-year serological observation was performed on the persistence of neutralizing antibodies after inoculation with JE live vaccine. The results showed that a total of 28 serum samples with pre-vaccination neutralizing antibody <1: 5 were positive for neutralizing antibody (96.4%) after 1 month of initial immunization (27/28, ≥ 1:10 ) Or 100.0% (2 8/2 8, ≥ 1: 5), one month after booster immunization was 100% (2 8/2 8, ≥ 1:10); one year after booster immunization was The positive rate of antibody at 6 years after booster immunization was 571% (16/2 8, ≥ 1:10) or 75 0% (2 1/2 8, ≥ 1: 5). The results showed that the positive rate of neutralizing antibody could still maintain at 51.7% -75.0% after immunization with 1 dose of JE live vaccine for 1 month and 1 year after boosting to 6 years after booster immunization. Show that JE live vaccine has good immune persistence.