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非经典人类白细胞抗原G(human leukocyte antigen-G,HLA-G)是机体内一类重要的免疫调节分子,包括膜结合型HLA-G(mHLA-G)及可溶性HLA-G(sHLA-G)两种分子表达形式。HLA-G分子可通过与受体结合直接抑制多种免疫活性细胞的生物学功能,或通过诱导产生免疫调节细胞间接抑制机体的免疫应答。研究显示,HLA-G基因多态性及分子表达在母胎免疫、感染、自身免疫病及肿瘤的发生发展中均有重要意义。对HLA-G在自身免疫病中的作用作一综述。
Human leukocyte antigen-G (HLA-G) is an important class of immunoregulatory molecules in the body including membrane-associated HLA-G (mHLA-G) and soluble HLA-G (sHLA-G) Two molecular forms of expression. HLA-G molecules can directly inhibit the biological function of a variety of immunocompetent cells by binding to the receptor or indirectly inhibit the body’s immune response by inducing the production of immunoregulatory cells. Studies have shown that HLA-G gene polymorphisms and molecular expression are important in the development of maternal-fetal immunity, infection, autoimmune diseases and tumors. The role of HLA-G in autoimmune diseases is reviewed.