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目的了解本地区抗菌药物尤其是头孢他啶使用量的变化,探讨其对鲍曼不动杆菌(Ab)耐药情况的影响。方法统计本地区2007-2008年用药人/次排序列前9位的抗菌药物使用量与Ab耐药率,并进行相关性分析。结果头孢他啶使用量与下季度Ab对头孢他啶和其它7种抗菌药的耐药率呈线性关系(P<0.05),其它结果差异无统计学意义。结论头孢他啶的使用量与Ab对多种抗菌药物耐药性的发展有关。
Objective To understand the changes of antibacterials, especially ceftazidime, in the area and investigate its effect on the drug resistance of Acinetobacter baumannii (Ab). Methods The top 9 antibacterial drug use rates and Ab drug resistance rates of the top 9 drug users in the region from 2007 to 2008 were statistically analyzed. Results There was a linear relationship between the amount of ceftazidime used and the Ab resistance rate of ceftazidime to the other seven antibacterials in the next quarter (P <0.05). Other results showed no significant difference. Conclusion The use of ceftazidime is related to the development of Ab resistance to various antimicrobial agents.