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选用脑死亡2～4小时后成年男性(20～40岁)新鲜心脏的三尖瓣瓣叶、腱索和乳头肌标本各20例,用生物化学方法测定了瓣叶、腱索、乳头肌尖部和乳头肌基部内羟脯氨酸(hydroxyprolin,HX)和氨基已糖(aminohexose,AH)的含量(μg/100mg组织),结果依次为1435.00±138.46和1670.33±358.39.2156.26±309.38和2156.26±309.38和1324.16±428.37、543.25±115.94和1267.50±105.23、347.50±80.48和1238.00±202.71.上述各部内HP的含量比值依次为1:1.50:0.39:0.24;AH为1:0.79:0.76:0.74.HP在腱索内含量最高,瓣叶内次之,乳头肌内最低.AH在瓣叶内含量最高.结果提示腱索和瓣叶是富含HP和AH的组织,这与形态学上观察到的腱索和瓣叶内胶原纤维密集的结果相符.此结果为进一步研究瓣膜装置的生化成分和对心瓣膜疾病的诊断、治疗提供参考资料.
Twenty leaflets, chordae and papillary muscle samples of fresh heart of adult male (20-40 years old) were selected from 2 to 4 hours after brain death. The biochemical parameters of the valve leaflets, the chordae, the tip of the papillary muscles And hydroxyprolin (HX) and aminohexose (AH) contents (μg / 100 mg tissue) in the papillary muscle base were 1435.00 ± 138.46 and 1670.33 ± 358.39.2156.26 ± 309.38 and 2156.26 ± 309.38 And 1324.16 ± 428.37, 543.25 ± 115.94 and 1267.50 ± 105.23, 347.50 ± 80.48 and 1238.00 ± 202.71, respectively. The content ratio of HP in each part was 1: 1.50: 0.39: 0.24, AH: 1: 0.79: 0.76: 0.74 Chondrocytes, chondrocytes, chondrocytes, chondrocytes, chondrocytes, chondrocytes, chondrocytes, chondrocytes, chondrocytes, chondrocytes, chondrocytes, The results of the cord and the collagen fibers in the valve leaflets were in good agreement with each other.The results provide reference materials for the further study on the biochemical composition of valve devices and the diagnosis and treatment of heart valve diseases.