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目的:分析血糖变异度与老年代谢综合征患者认知功能障碍的相关性，为早期诊断认知功能障碍提供参考。方法:选择中国人民武装警察部队四川省总队医院2017年12月至2019年3月诊治80例老年代谢综合征患者作为研究组和50例同期体检的健康老年人作为对照组，比较两组一般资料、生化指标等的差异。老年代谢综合征患者入院时采用蒙特利尔认知评估量表（MoCA）测评认知功能，按照MoCA得分将患者分为认知功能障碍组和认知功能正常组。患者入院24 h内进行72 h动态血糖监测，比较两组72 h内平均血糖（Glun Ave）、血糖标准差（Glun SD）、24 h内平均血糖波动幅度（MAGE）、血糖不稳定指数（GLI）、血糖变异系数（Glun CV）和其他临床指标的差异。n 结果:与对照组比较，研究组体质量指数（BMI）、收缩压（SBP）、舒张压（DBP）、空腹血糖（FPG）、三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、糖化血红蛋白（HbAn 1c）明显升高[（25.48 ± 3.86）kg/mn 2比（22.83 ± 4.60）kg/mn 2、（139.09 ± 10.17）mmHg（1 mmHg=0.133kPa）比（128.12 ± 7.8）mmHg、（73.00 ± 6.65）mmHg比（69.90 ± 5.99）mmHg、（9.12 ± 1.54）mmol/L比（4.92 ± 0.63）mmol/L、（2.17 ± 0.49）mmol/L比（1.70 ± 0.48）mmol/L、（5.32 ± 0.62）mmol/L比（4.61 ± 0.45）mmol/L、（3.05 ± 0.79）mmol/L比（2.31 ± 0.53）mmol/L、（7.89 ± 1.92）%比（5.30 ± 0.56）%]，高密度脂蛋白胆固醇（HDL-C）明显降低[（0.98 ± 0.25）mmol/L比（1.19 ± 0.43）mmol/L]，差异有统计学意义（n P1.11 mmol/L（曲线下面积0.821）时，提示有发生认知功能障碍的风险。n 结论:Glun Ave、Glun SD、MAGE、GLI、Glun CV与老年代谢综合征患者认知功能障碍有关，Glun SD、MAGE可作为预测认知功能障碍的指标。n “,”Objective:To investigate the clinical significance and correlation between blood glucose variability and cognitive impairment in elderly patients with metabolic syndrome.Methods:A total of 80 elderly metabolic syndrome patients and 50 healthy controls in Chinese People′s Armed Police Corps Hospital in Sichuan Province from December 2017 to March 2019 were selected as study group and control group respectively, and the difference of general data and biochemical indicators between two groups were compared. The cognitive function of the metabolic syndrome patients was measured by Montreal cognitive assessment scale (MoCA) at admission. The patients were divided into cognitive dysfunction group and normal cognition group according to MoCA score. The glycemic variability was detected by 72-h dynamic monitoring of blood glucose started within 24 h after admission, and the difference of average blood glucose (Glun Ave), standard deviation of glucose (Glun SD), mean amplitude of glycemic excursions in 24 h (MAGE), glycemic index (GLI), glucose variability (Glun CV) and other indicators between cognitive dysfunction group and normal cognition group were also compared.n Results:The levels of body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG), triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterin (LDL-C), glycated hemoglobin (HbAn 1c) were significantly increased in the study group [(25.48 ± 3.86) kg/mn 2 vs. (22.83 ± 4.60) kg/mn 2, (139.09 ± 10.17) mmHg (1 mmHg = 0.133 kPa) vs. (128.12 ± 7.8) mmHg, (73.00 ± 6.65) mmHg vs. (69.90 ± 5.99) mmHg, (9.12 ± 1.54) mmol/L vs. (4.92 ± 0.63) mmol/L, (2.17 ± 0.49) mmol/L vs. (1.70 ± 0.48) mmol/L, (5.32 ± 0.62) mmol/L vs. (4.61 ± 0.45) mmol/L, (3.05 ± 0.79) mmol/L vs. (2.31 ± 0.53) mmol/L, (7.89 ± 1.92)% vs. (5.30 ± 0.56)%], high density lipoprotein cholesterol (HDL-C) were significantly decreased in the study group [(0.98 ± 0.25) mmol/L vs. (1.19 ± 0.43) mmol/L] compared to the control group, and the differences were statistically significant (n P1.11 mmol/L (AUC = 0.821) may indicated the occurrence of cognitive impairment.n Conclusions:Glun Ave, Glun SD, MAGE, GLI and Glun CV are all correlated with cognitive dysfunction in elderly patients with metabolic syndrome, and Glun SD and MAGE may be considered as a potential maker for prediction of cognitive dysfunction.n