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从脑脊液(CSF)中分离出脊髓灰质炎病毒(PV)极为罕见,通常与宿主因素相关。例如免疫缺陷状态和脑室-腹膜分流术。该文首次报道1例婴儿因口服脊髓灰质炎疫苗后,发生持续性发热和腺病毒双重感染,并从其CSF中分离出PV2型。病例男孩,6月龄,日本国东京人。因持续高热(体温40℃)14天,咳嗽和腹泻10天,呕吐2天而入院。入院前26天曾接受首剂口服脊髓灰质炎疫苗。患儿为第1胎足月分娩,混合喂养。CSF含单个核细胞1/mm~3,葡萄糖57mg/dl,蛋白19mg/dl。血清IgG、IgA和IgM分别为917mg/dl,55mg/dl和221mg/dl。
Poliovirus (PV) isolation from cerebrospinal fluid (CSF) is extremely rare and is often associated with host factors. Such as immunodeficiency status and ventricular-peritoneal shunts. This paper reports for the first time that one infant developed persistent fever and adenovirus double infection after oral polio vaccine and isolated PV2 from its CSF. Case boy, 6 months old, Tokyo, Japan. Due to persistent high fever (body temperature 40 ℃) for 14 days, cough and diarrhea for 10 days, vomiting for 2 days and admitted to hospital. The first oral oral polio vaccine was received 26 days before admission. Children with first-term full-term childbirth, mixed feeding. CSF containing mononuclear cells 1 / mm ~ 3, glucose 57mg / dl, protein 19mg / dl. Serum IgG, IgA and IgM were 917 mg / dl, 55 mg / dl and 221 mg / dl, respectively.