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目的 :评价接触锰对下丘脑 -垂体 -睾丸轴的影响 ,为保护工人生殖健康提供科学的参考依据。方法 :应用放射免疫法测定了 184名健康男工的血浆睾酮 (T)、血清促间质细胞激素 (L H)和促卵泡成熟激素 (FSH )含量 ,其中锰粉加工、冶炼、焊接和对照工人分别为 36 ,5 0 ,2 4和 74人。结果 ::冶炼作业环境空气中 Mn O2 浓度几何均值为 0 .17m g/ m3,工人血清 L H、 FSH含量高于对照组 (P <0 .0 5～ 0 .0 1) ,而血浆 T浓度正常。接锰工龄 5～ <10年的工人血清 FSH含量比对照组高 (P <0 .0 5 )。逐步回归分析显示血浆 T与空气锰浓度呈负相关 ,但分层分析未见显著性差异。结论 :锰对下丘脑 -垂体-睾丸轴的继发作用明显。
Objective: To evaluate the effect of exposure to manganese on hypothalamic-pituitary-testicular axis and provide a scientific reference for the protection of reproductive health of workers. Methods: The contents of plasma testosterone (T), serum levels of somatotrophs (LH) and follicle stimulating hormone (FSH) in 184 healthy male workers were determined by radioimmunoassay. Among them, the processing, smelting, welding and control workers 36, 50, 24 and 74 respectively. Results: The geometrical mean value of Mn O2 in the air of smelting operation was 0.17 m g / m 3, the serum levels of LH and FSH in workers were higher than those in the control group (P <0.05-0.01), while the plasma T concentrations were normal . Serum FSH levels in workers who received manganese for 5 to 10 years were higher than those in the control group (P <0.05). Stepwise regression analysis showed that plasma T was negatively correlated with air manganese concentration, but no significant difference was found by stratified analysis. Conclusion: The secondary effect of Mn on hypothalamus-pituitary-testis axis is obvious.