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目的:研究超声造影在射频消融治疗复发性肝细胞性肝癌(RHCC)疗效评估中的应用价值。方法:纳入2018年4月至2020年4月于新乡医学院第一附属医院接受射频消融治疗的RHCC患者78例，根据肿瘤长径将患者分为A组(肿瘤长径>3 cm，24例)和B组(肿瘤长径≤3 cm，54例)，分别在射频消融治疗后24 h及1、3、6个月时行超声造影检查。比较两组复发率，并评估超声造影对射频消融治疗RHCC患者临床疗效的价值。结果:治疗后3、6个月，A组复发率分别为16.67%(4/24)、20.83%(5/24)，高于B组的0、3.70%(2/54)，差异有统计学意义(n P<0.05)。治疗后3、6个月，达峰时间(TTP)及平均渡越时间(MTT)对判断射频消融疗效具有一定应用价值(n P<0.05)。治疗后6个月，TTP和MTT判断B组患者射频消融疗效的受试者工作特征曲线下面积值高于A组，差异有统计学意义(n P3 cm, 24 cases) and group B (tumor diameter≤3 cm, 54 cases) according to the diameter of the tumor. The CEUS examinations were performed at 24 hours, 1 month, 3 months and 6 months after RFA treatment. The recurrence rates of the two groups were compared, and the value of CEUS in evaluating the efficacy of patients with RHCC after RFA treatment was evaluated.Results:The 3-month and 6-month postoperative recurrence rates in group A were 16.67%(4/24) and 20.83%(5/24), respectively, significantly higher than the 0, 3.70%(2/54) in group B (n P<0.05). The time to peak (TTP) and mean transit time (MTT) had certain application value in judging the efficacy of RFA at 3 and 6 months after treatment (n P<0.05). The area under receiver operating characteristic curve of TTP and MTT at 6 months after treatment to judge the RFA curative effect in group B was significantly higher than that in group B, and the difference was statistically significant (n P<0.05).n Conclusions:The CEUS is helpful to evaluate the effects of RFA treatment for RHCC, especially for the patients with tumors diameter less than 3 cm, and it has a high accuracy.