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目的：探讨原发性肾病综合征（ ＮＳ） 患儿血小板活化程度在诊断高凝状态中的价值。 方法：采用流式细胞仪检测３８ 例ＮＳ 患儿外周血血小板颗粒膜蛋白（ ＣＤ６２Ｐ） 、溶酶体颗粒膜蛋白（ＣＤ６３） 及凝血酶敏感蛋白（ ＴＳＰ） ，同时检测了血管内皮细胞标志、凝血、抗凝及纤溶指标。 结果： 与对照组比较，ＮＳ 患儿肾病期血小板ＣＤ６２Ｐ、ＣＤ６３ 及ＴＳＰ 表达率明显增高，缓解期接近正常，ＣＤ６２Ｐ、ＣＤ６３ 与ＰＡｇＴ、ＶＷＦ、ＰＡＩ 及ＦＤＰ 呈明显正相关，与ＡＴⅢ：Ａｇ 、ＡＴⅢ：ａｃ 呈明显负相关；ＴＳＰ 与ＶＷＦ、ＰＡＩ 正相关。结论：提示血小板活化与ＮＳ 高凝状态的发生有关，ＣＤ６２Ｐ 及ＣＤ６３ 为早期诊断高凝状态的敏感指标。
Objective: To investigate the value of platelet activation in children with primary nephrotic syndrome (NS) in the diagnosis of hypercoagulable state. Methods: Flow cytometry was used to detect CD62P, CD63 and TSP in peripheral blood of 38 children with NS. The levels of vascular endothelial cell markers, blood coagulation Anticoagulation and fibrinolysis. Results: Compared with the control group, the expression of CD62P, CD63 and TSP in platelet of nephrotic patients with nephropathy in NS group was significantly higher than that in control group, and the remission was close to normal. CD62P and CD63 were positively correlated with PAgT, VWF, PAI and FDP, , AT Ⅲ: ac showed a significant negative correlation; TSP and VWF, PAI positive correlation. Conclusion: It is suggested that platelet activation is related to the occurrence of hypercoagulable state in NS. CD62P and CD63 are sensitive indicators for early diagnosis of hypercoagulable state.