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目的探讨腺苷脱氨酶(ADA)、C反应蛋白(CRP)及肿瘤标志物癌胚抗原(CEA)、糖链抗原153(CA153)联合检测在胸腔积液鉴别诊断中的价值。方法选取62例结核性胸腔积液患者(结核组)和33例恶性胸腔积液患者(恶性组)作为研究对象,抽取胸腔积液,采用酶联免疫吸附试验检测ADA和免疫投射比浊法检测CRP,电化学发光法检测CEA和CA153,比较两组患者的检测结果。结果结核组胸腔积液ADA和CRP水平和阳性率均显著高于恶性组,差异具有统计学意义(P<0.05);CEA和CA153水平和阳性率显著低于恶性组,差异具有统计学意义(P<0.05)。结论 ADA、CRP联合肿瘤标志物CEA和CA153检测对胸腔积液的鉴别诊断具有一定的价值,值得临床推广。
Objective To investigate the value of combined detection of adenosine deaminase (ADA), C-reactive protein (CRP), carcinoembryonic antigen (CEA) and carbohydrate antigen 153 (CA153) in the differential diagnosis of pleural effusion. Methods Sixty-two patients with tuberculous pleural effusion (tuberculosis group) and 33 patients with malignant pleural effusion (malignant group) were selected as study objects. Pleural effusion was collected and the ADA and immunoprecipitation turbidimetric assay CRP, CEA and CA153 were detected by electrochemiluminescence, and the results of two groups were compared. Results The levels and positive rates of ADA and CRP in tuberculosis group were significantly higher than those in malignant group (P <0.05). The levels and positive rates of CEA and CA153 in malignant group were significantly lower than those in malignant group P <0.05). Conclusion The combined detection of CEA and CA153 by ADA and CRP has certain value in the differential diagnosis of pleural effusion and is worthy of clinical promotion.