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目的 研究鼻咽癌 (NPC)的CT影像所表现的深层蔓延程度、预后与P5 3的关系 ,更全面的认识NPC的生物学特性。方法 收集放疗前进行过CT检查并有详细临床记录的NPC活检标本 70例 ,采用S -P法进行P5 3免疫组织化学染色 ,详细分析P5 3蛋白表达与NPC局部蔓延情况和临床预后的关系。结果 本组NPC ,P5 3阳性表达率 6 8.5 7% ,其与组织学类型和病理分级无关 ;Ⅱ型和Ⅲ型NPC的P5 3阳性率高于Ⅰ型NPC ;P5 3的表达与有无颈淋巴结转移无关 ,但与转移颈淋巴结大小有关 ,即 <4cm者的P5 3阳性率高于≥ 4cm者 ;P5 3表达与NPC放疗后局部复发和远处转移无关。结论 随肿瘤向鼻咽深层蔓延 ,P5 3阳性表达率增高 ,恶性程度加大 ,按CT影像所分 3种类型 ,反映了NPC的生物学特性。
Objective To study the deep spread of NPC in NPC and the relationship between prognosis and P5 3 and to understand the biological characteristics of NPC more fully. Methods 70 cases of NPC biopsy specimens with CT examination before radiotherapy and detailed clinical records were collected. P5 3 immunohistochemical staining was performed by S-P method. The relationship between the expression of P53 protein and the local spread of NPC and clinical prognosis was analyzed in detail. Results The positive expression rate of P53 in NPC was 6 8.57%, which was not related to the histological type and pathological grade. The positive rate of P53 in type Ⅱ and type Ⅲ NPC was higher than that in type Ⅰ NPC. The expression of P53 and the presence or absence of neck Lymph node metastasis but not related to the size of the metastatic neck lymph nodes, that is, the positive rate of P5 3 in patients <4 cm is higher than ≥ 4 cm; the expression of P53 is not related to the local recurrence and distant metastasis after NPC radiotherapy. Conclusion With the spread of tumors to deep nasopharyngeal tissues, the positive rate of P5 3 is increased and the degree of malignancy is increased. According to CT images, the three types of P53 reflect the biological characteristics of NPC.