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目的 :探讨血管内皮细胞生长因子 (VEGFmRNA)和碱性成纤维细胞生长因子 (bFGFmRNA)在原发性肝癌中的表达及其意义。方法 :应用原位杂交技术检测 38例原发性肝癌VEGFmRNA和bFGFmRNA的表达情况。结果 :VEGFmRNA和bFGFmRNA阳性率与原发性肝癌门静脉和 /或胆管癌栓形成有关 ,伴癌栓病例VEGFmRNA和bFGFmRNA阳性率分别为 84 .6 %和 88.5 % ,不伴癌栓病例阳性率分别为 33.3%和2 5 .0 % ,两者比较均有显著差异 (P <0 .0 5 )。结论 :VEGFmRNA和bFGFmRNA可作为原发性肝癌的预后指标 ,可望为抑制原发性肝癌血管生成治疗提供实验依据和新线索
Objective: To investigate the expression of vascular endothelial growth factor (VEGFmRNA) and basic fibroblast growth factor (bFGFmRNA) in primary hepatocellular carcinoma and its significance. Methods: The expression of VEGF mRNA and bFGF mRNA in 38 cases of primary hepatocellular carcinoma was detected by in situ hybridization. Results: The positive rates of VEGF mRNA and bFGF mRNA were associated with the formation of portal vein and / or cholangiocarcinoma in primary hepatocellular carcinoma. The positive rates of VEGF mRNA and bFGF mRNA in patients with tumor thrombus were 84.6% and 88.5%, respectively. The positive rates of VEGF mRNA and bFGF mRNA were 33.3% and 25.0%, both of which were significantly different (P <0.05). Conclusion: VEGF mRNA and bFGF mRNA can be used as prognostic indicators of primary liver cancer, which may provide experimental evidence and new clues for the inhibition of angiogenesis in primary liver cancer