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目的:研究单侧喉返神经(RLN)切断后,两侧甲杓肌纤维所发生的酶组织化学变化。方法:建立单侧RLN麻痹动物模型,应用琥珀酸脱氢酶染色法及显微图像分析仪,动态观察双侧甲杓肌中各型肌纤维直径的变化。结果:去RLN侧4周时各型肌纤维萎缩有意义(P<0.05);10周时,已分辨不出肌型,肌纤维呈纤溶性改变。健侧甲杓肌,4周时直径已发生代偿改变,各型肌纤维均增粗(P<0.05);10周时代偿尤为显著,其中以中间肌纤维代偿最为明显,各型肌纤维构成比没有明显变化趋势。结论:当发生单侧RLN麻痹时,健侧甲杓肌各型肌纤维均增粗,以中间肌纤维最明显,对喉的功能起到一定的代偿作用。
OBJECTIVE: To study the enzymatic histochemical changes of the muscle fibers of the left side of the laryngeal muscle fibers after the unilateral recurrent laryngeal nerve (RLN) is cut off. Methods: The model of unilateral RLN paralysis was established. The changes of the diameter of muscle fibers in each side of the two cases were observed dynamically by succinate dehydrogenase staining and microscopic image analyzer. Results: At 4 weeks after RLN, the atrophy of each type of muscle fiber was significant (P <0.05). At 10 weeks, no muscle type was observed and fibrinolytic changes of muscle fibers were observed. The contralateral hemifacial muscle had compensatory changes in diameter at 4 weeks, and all kinds of muscle fibers were thicker (P <0.05). At 10 weeks, the compensations were particularly significant, of which the compensatory muscle fibers were the most obvious No obvious change trend. CONCLUSION: When unilateral RLN paralysis occurs, all types of muscle fibers in the contralateral lariform muscle are thicker, and the fibers in the middle muscle are the most obvious. They play a compensatory role in the function of the larynx.