环腺苷酸(cAMP)是生物体的重要活性物质,具有广泛的生理生化效应,与许多疾病的发生或治疗都有关系。许多中药的补益或治疗作用也是通过cAMP 途径而取效。cAMP-磷酸二酯酶(cAMP-PDE)水解cAMP,该酶几乎存在于人体所有细胞中,对cAMP 水平有重大影响。研究中药对该酶的抑制作用不仅为阐明中药的某些治疗效果的机理有一定意义,还为临床提供有效的cAMP-PDE 抑制剂开辟新途径。现将对cAMP-PDE 有抑制作用的中药及其成分综述于下。皂甙类 Cyclic adenosine acid (cAMP) is an important biological activity of the body, has a wide range of physiological and biochemical effects, and many diseases are related to the occurrence or treatment. Many Chinese medicine replenishment or therapeutic effect through the cAMP pathway is also effective. cAMP-phosphodiesterase (cAMP-PDE) hydrolyzes cAMP, which is found in almost all cells in the body and has a significant effect on cAMP levels. To study the inhibitory effect of traditional Chinese medicine on this enzyme not only has some significance for elucidating the mechanism of certain therapeutic effects of traditional Chinese medicine, but also opens up new avenues for providing effective cAMP-PDE inhibitors clinically. Now on cAMP-PDE inhibitory effect of traditional Chinese medicine and its ingredients are summarized below. Saponins