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目的:探讨放疗、热疗对细胞因子的影响。方法:选择健康雄性大白兔60只,将实验动物随机分为放疗组20只、热疗组20只、对照组20只。移植VX2瘤株12 d后,对实验组动物进行放疗、热疗照射,对照组不治疗,监测白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF)、胰岛素样生长因子(IGF)的变化。结果:实验动物生存期较对照组延长15 d左右。IL-2在血清中的含量逐渐降低,降低幅度与病死率相关;IL-6、IGF的含量逐渐增高,增高幅度越大则病死率越高,对照组变化最大;TNF逐渐增高,放疗组和热疗组变化幅度大,生存期提高。结论:放疗对VX2瘤效果好,对细胞因子有一定的影响;热疗是治疗肿瘤重要的辅助疗法,有提高免疫功能的作用。
Objective: To investigate the effects of radiotherapy and hyperthermia on cytokines. Methods: Sixty healthy male rabbits were selected. The experimental animals were randomly divided into radiotherapy group (n = 20), hyperthermia group (n = 20) and control group (n = 20). After transplanted VX2 tumor cells for 12 days, the experimental animals were treated with radiotherapy and hyperthermia, while the control group were untreated. The levels of interleukin 2 (IL-2), interleukin 6 (IL-6), tumor necrosis factor (TNF), insulin-like growth factor (IGF) changes. Results: The survival time of experimental animals than the control group extended about 15 d. The content of IL-2 in serum gradually decreased, and the rate of decrease was related to the case fatality rate. The content of IL-6 and IGF gradually increased. The higher the mortality was, the higher the mortality was and the highest was in control group. Hyperthermia group changes in magnitude, increased survival. Conclusion: Radiotherapy has a good effect on VX2 tumor and has certain influence on cytokines. Hyperthermia is an important adjuvant therapy for tumor and has the function of improving immune function.