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报道了二氢埃托啡透皮贴片系统（ＤＨＥ－ＴＤＳ）的研制情况，并对该系统进行了初步动物实验，结果说明，以ＰＶＡ，ＰＶＰ、乳糖等为主要基质制成的ＤＨＥ－ＴＤＳ对皮肤的刺激性属轻度，用家兔腹部贴片。测定药库中药物剩余量，结果推知药物释放符合一级原理。大鼠实验证明，ＤＨＥ－ＴＤＳ稳定释药时间为用药后４一３２ｈ，大鼠扭体实验证明ＤＨＥ－ＴＤＳ一次用药，镇痛作用持续时间至少４８ｈ。此制剂是否有成瘾性，尚待证明。
The development of DHE-TDS system was reported and preliminary animal experiments were conducted on the system. The results showed that DHE-TDS with DHP-TDS Skin irritation is mild, the rabbit abdomen patch. Determination of drug residue in the library, the results deduced drug release in line with a principle. The rat experiment proved that the stable release time of DHE-TDS was 4 to 32 hours after the administration, and the writhing test in rats demonstrated that DHE-TDS was administered once and the duration of analgesic effect was at least 48 hours. Whether this preparation is addictive has yet to be demonstrated.