Ｄ Ｎ Ａ 测序是遗传工程的重要技术之一， Ｄ Ｎ Ａ 测序技术的自动化对遗传工程的研究具有重要意义。七十年代末期， Ｓａｎｇｅｒ 和 Ｍａｘａｍ 、 Ｇｉｌｂｅｒｔ分别提出了切实可行的 Ｄ Ｎ Ａ序列测定方法。近二十年来， Ｄ Ｎ Ａ 测序技术发展很快。人们从不同方面对该技术进行了改进，并将许多先进的光学探测方法应用于 Ｄ Ｎ Ａ 测序技术中。目前已出现了许多商品化的 Ｄ Ｎ Ａ 测序仪 D N A sequencing is one of the important technologies in genetic engineering. The automation of D N A sequencing technology is of great significance to the research of genetic engineering. In the late seventies, Sanger and Maxam, Gilbert proposed a practical D N A sequence determination method. Nearly two decades, D N A sequencing technology has developed rapidly. People from different aspects of the technology has been improved, and many advanced optical detection methods used in D N A sequencing technology. A number of commercially available D N A sequencers have emerged