报道了微波促进无溶剂条件下二酰基肼可以良好产率脱水闭环得到 2 ,5 二取代 1 ,3 ,4 二唑衍生物。反应产率受取代基影响较大 ,苯基取代时产率较高 ,烷基取代时产率较低 ;反应产率与所用的无机支持体有关 ,其中以酸性三氧化二铝的效果最佳。此法不仅环境友好且操作安全 ,避免使用化学脱水剂。 It has been reported that diacylhydrazine can be dehydrated and ring-closed with good yield under microwave-assisted and solvent-free conditions to obtain 2,5-disubstituted 1,3,4-oxadiazole derivatives. The yield of the reaction is greatly influenced by the substituent, the yield is higher when the phenyl group is substituted and the yield is lower when the alkyl group is substituted. The yield of the reaction is related to the inorganic support used, and the acid aluminum oxide is most effective . This method is not only environmentally friendly and safe operation, to avoid the use of chemical dehydration agent.