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为了探讨血清唾液酸与肾病类型及症状的关系,本文分别观察了阿霉素性微小病变型肾病综合征大鼠(肾病鼠)和急性血清病肾炎家兔(肾炎兔)。结果显示:①两种动物模型的血清唾液酸(serum sialic acid,SSA)均明显升高。②肾病鼠SSA分别与尿蛋白含量、血清白蛋白、血清胆固醇以及肾小球上皮细胞是突裂隙数分别呈密切直线相关;③肾炎兔SSA与尿蛋白含量呈正相关,与肾小球细胞数的变化相平行。结果提示,SSA升高与肾病类型无关,而与肾脏病变程度有一定联系。
In order to investigate the relationship between serum sialic acid and nephropathy types and symptoms, we observed adriamycin-induced nephrotic syndrome (nephrotic syndrome) and acute serum nephritis (nephritis) rabbits respectively. The results showed that: ① Serum sialic acid (SSA) of both animal models were significantly increased. (2) SSA in nephritic rats was closely related to urinary protein content, serum albumin, serum cholesterol and glomerular epithelial cells, respectively; ③The SSA of nephritic rabbits was positively correlated with urinary protein content and the number of glomerular cells The changes are parallel. The results suggest that elevated SSA has nothing to do with the type of kidney disease, but with a certain degree of renal disease.