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糖尿病的病因至今尚未阐明,目前主要趋向胰岛素分泌绝对不足或相对不足及胰高血糖素分泌过多为糖尿病的基本发病原理。为了探讨糖尿病的病因及发病原理,对健康人及糖尿病患者分别测定空腹血浆皮质醇、胰岛素(放射免疫测定法)及血糖水平(福一吴氏法),发现23例糖尿病患者中,有17例胰岛素水平高于正常,23例糖尿病患者胰岛素水平的均值亦高于正常;皮质醇水平高于正常;而血糖水平不随皮质醇分泌的昼夜波动规律而波动。
The etiology of diabetes has not yet been elucidated, at present the main trend of insulin secretion is definitely inadequate or relatively inadequate and excessive glucagon secretion for the basic pathogenesis of diabetes. In order to explore the etiology and pathogenesis of diabetes mellitus, fasting plasma cortisol, insulin (radioimmunoassay) and blood glucose levels (Fu-Wu method) were measured in healthy people and patients with diabetes mellitus, found that in 23 cases of diabetic patients, 17 cases Insulin levels were higher than normal. The mean insulin level in 23 patients with diabetes was also higher than normal; the level of cortisol was higher than normal; and the blood glucose level did not fluctuate with the circadian rhythm of cortisol secretion.