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节律活动是生命的基本特征。已经证明人和动物许多生理功能及病理变化表现出明显的昼夜节律。小鼠外周血白细胞数也不例外,并具有较高的重演性,是研究时间药效较理想的材料之一。我们观察了ICR、昆明、BALB/c、615、DBA、C 57 BL等6个不同种系小鼠在8:00至20:00和615小鼠在24小时内的白细胞节律变化,以及取血顺序和间隔对结果的影响。材料和方法 615、DBA、BALB/c、ICR、C 57 BL、昆明6个种系小鼠,6～12周龄,体重20～25克。大部分由本院动物房供给,少量来自上海兄弟单位,铝皮饲养箱为30×15×10 cm。采用自然光照。冬季以煤气取暖,室温在20℃左右。夏季空调,室温在30℃左右。饲料为
Rhythm activity is the basic characteristics of life. It has been shown that many physiological functions and pathological changes in humans and animals show significant circadian rhythms. Mouse peripheral blood leukocyte count is no exception, and has a high repetition, is one of the more ideal time to study the efficacy of the material. We observed changes in white blood cell rhythms in ICR, Kunming, BALB / c, 615, DBA, C 57 BL and other 6 different germline mice from 8:00 to 20:00 and 615 mice within 24 hours, The effect of sequence and interval on the result. MATERIALS AND METHODS 615, DBA, BALB / c, ICR, C 57 BL, Kunming 6 germline mice, 6-12 weeks old, weighing 20-25 grams. Most of them are supplied by our hospital animal room, and a small amount comes from Shanghai Brothers Units. The aluminum skin feeder is 30 × 15 × 10 cm. Use natural light. Winter to gas heating, room temperature at about 20 ℃. Summer air conditioning, room temperature at about 30 ℃. Feed for