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急性心梗(AMI)再灌注期间,组织损伤的原因之一是氧自由基的有害作用。氧自由基通过脂质过氧化反应攻击细胞的脂质成份,造成细胞膜及细胞其他成份的损伤或死亡。脂质过氧化反应过程中产生的戊烷可随呼吸排出体外,目前认为呼气中戊烷浓度是一种敏感和直接反映脂质过氧化反应程度的指标。为了观察心肌缺血后再灌注期间由氧自由基介导的细胞脂质过氧化反应性损伤,作者测定10例健康人(正常对照组)、10例拟诊AMI而心电图没有相应表现者(病人对照
Acute myocardial infarction (AMI) One of the causes of tissue damage during reperfusion is the detrimental effect of oxygen free radicals. Oxygen free radicals attack the lipid components of the cells by lipid peroxidation, resulting in damage or death of the cell membranes and other cellular components. Pentane produced during the lipid peroxidation process can be excreted with the breath, the current concentration of pentane in the expiration is a sensitive and direct indicator of the degree of lipid peroxidation. In order to observe the oxidative damage of lipid peroxidation induced by oxygen free radicals during myocardial ischemia and reperfusion, we measured 10 healthy subjects (normal control group), 10 patients with suspected AMI and no corresponding ECG (patients Control