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目的 :ＯＰＨ是本研究所合成的创新化合物 ,对心血管系统有明显活性。以往的研究显示它对冠脉阻断 -再灌或全心停灌 -复灌所致心肌损伤有明显保护作用 ,为探讨其作用的生化机制 ,研究ＯＰＨ对再灌注心肌能量代谢的影响。方法 :大鼠Ｌａｎｇｅｎｄｏｒｆｆ氏心脏 ,Ｋ -Ｈ液灌流
OBJECTIVE: OPH is an innovative compound synthesized in this study and has obvious activity on cardiovascular system. Previous studies have shown that it has a significant protective effect on myocardial injury caused by coronary artery occlusion-reperfusion or cardioplegia-reperfusion. To investigate the biochemical mechanism of its effect and the effect of OPH on myocardial energy metabolism after reperfusion. Methods: Rats Langendorff’s heart, K-H fluid perfusion