目的：为探求粘附分子在蕈样肉芽肿（ ＭＦ） 病理形成机制中的作用。方法：采用免疫组化技术，检测了１６ 例ＭＦ皮损部位ＩＣＡＭ１／ＬＦＡ－ １ 和ＨＬＡＤＲ 的表达。结果：ＩＣＡＭ１／ＬＦＡ１ 和ＨＬＡＤＲ 在ＭＦ 表皮和／ 或毛囊上皮角朊细胞都有不同程度的表达，其中ＩＣＡＭ１ 的表达与ＭＦ 亲表皮性明显相关。结论：ＩＣＡＭ１／ＬＦＡ１ 在ＭＦ 亲表皮性形成过程中可能起着重要作用。 Objective: To explore the role of adhesion molecules in the pathological mechanism of mycosis fungoides (MF). Methods: Immunohistochemistry was used to detect the expression of ICAM1 / LFA1 and HLADR in 16 MF lesions. Results: ICAM  1 / LFA  1 and HLA  DR in the MF epidermis and / or hair follicle epithelial keratinocytes have different levels of expression, ICAM  1 expression was closely related with MF pro - skin. Conclusion: ICAM 1 / LFA 1 may play an important role in the formation of MF pro skin.