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目的探讨新生儿缺氧缺血性脑病(HIE)患儿血清白细胞介素-1β(IL-1β)水平的变化及其临床意义。方法选择我院儿科2010年7月至2011年6月收治的HIE患儿为HIE组,排除HIE的足月新生儿为对照组,采用酶联免疫吸附法检测两组患儿急性期(生后3天)和恢复期(生后7天)血清IL-1β的水平。HIE患儿按病情分为轻、中、重度3个亚组。结果生后3天和7天各组IL-1β水平(ng/ml)分别为[对照组:(21.9±6.0)和(21.4±5.0),轻度HIE组:(23.4±4.0)和(19.7±4.1),中度HIE组:(30.1±3.7)和(26.7±4.4),重度HIE组:(38.5±4.5)和(30.9±5.2)],中、重度HIE组明显高于轻度HIE组和对照组(P<0.01),重度HIE组高于中度HIE组(P<0.01),轻度HIE组与对照组比较差异无统计学意义(P>0.05)。各HIE组患儿7天时血清IL-1β水平均较3天时显著降低(P<0.01)。生后3、7天IL-1β水平与病情分度呈正相关[3天:r=0.80,7天:r=0.72,P均<0.01]。结论检测HIE患儿血清IL-1β水平对HIE的辅助诊断和病情判断有重要意义。
Objective To investigate the changes of serum interleukin-1β (IL-1β) in neonates with hypoxic-ischemic encephalopathy (HIE) and its clinical significance. Methods HIE children with HIE admitted from July 2010 to June 2011 in our hospital were selected as HIE group and full term newborns with HIE excluded as control group. Enzyme linked immunosorbent assay was used to detect the acute phase 3 days) and convalescent (7 days after birth) serum IL-1β levels. HIE children according to the disease is divided into mild, moderate and severe 3 subgroups. Results The levels of IL-1β (ng / ml) were [control group (21.9 ± 6.0) and (21.4 ± 5.0), mild HIE group: (23.4 ± 4.0) and ± 4.1), moderate HIE group (30.1 ± 3.7) and (26.7 ± 4.4), severe HIE group (38.5 ± 4.5) and (30.9 ± 5.2) respectively. The levels of HIE in moderate and severe HIE group were significantly higher than those in mild HIE group (P <0.01), severe HIE group was higher than moderate HIE group (P <0.01), there was no significant difference between mild HIE group and control group (P> 0.05). The levels of IL-1β in children with HIE at 7 days were significantly lower than those at 3 days (P <0.01). The level of IL-1β was positively correlated with the degree of disease 3 days and 7 days after birth [3 days: r = 0.80, 7 days: r = 0.72, P <0.01]. Conclusion The detection of serum IL-1β levels in children with HIE is of great significance for the diagnosis and diagnosis of HIE.