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在厄瓜多示盘尾丝虫病流行区居民中有两种临床现象引起了作者对氯喹是否有抗盘尾丝虫作用的注意。首先,常用报导盘尾丝虫病人服用500mg氯喹后出现皮肤强烈的搔痒感,一般持续24小时而无任何皮肤病可见。这种症状只发现于美洲土著和黑人,给服60mg去氢可的松可抑制这种搔痒症。在服用氯喹的厄瓜多尔人中不曾有此报导。其次,服用氯喹与少受盘尾丝虫感染两者间存在正相关。如在盘尾丝虫病流行区的两个村庄中,A村居民每人每周服氯喹500mg,B村则无,结果A村居民盘尾丝虫患病率为
In Ecuador, there are two clinical manifestations of residents in the endemic area of onchocerciasis arousing the concern that chloroquine has an effect against onchocerciasis. First of all, it is commonly reported that onchocerciasis patients have a strong pruritus of the skin after taking 500 mg of chloroquine, which usually lasts for 24 hours without any dermatosis. This symptom was found only in Native Americans and Negroes, and 60 mg of hydrocortisone was administered to suppress this pruritus. This has not been reported among Ecuadorians taking chloroquine. Second, there was a positive correlation between chloroquine and less onchocerciasis infection. For example, in the two villages where endemic filariasis is endemic, A village residents each took chloroquine 500 mg weekly, while B village did not. As a result, the prevalence of onchocerciasis in village A was