论文部分内容阅读
本文参考国外有关吗啡依赖猴、狗及大鼠的戒断症状分级标准，结合本所的实验经验，制定了用药物治疗吗啡依赖猴的实验方法及疗效评定标准。该标准将吗啡戒断症状分为轻、中、重和极重四个等级，并根据戒断症状的等级和出现的频率进行评分。评分标准为级差分加症状分。当治疗结束时，将各给药组的戒断症状分值和体重下降百分率分别相加，求出总平均分值和体重下降百分率．然后进行组间ｔ检验。另外还要将各组猴在治疗期内戒断症状出现的频次与ＮＳ组进行比较以全面了解某个药物对哪些戒断症状能完全抑制，哪些不能控制，甚至加重。药物的疗效靠上述情况综合判断。本文以治非西定为例说明该标准的应用情况。
In this paper, reference to foreign morphine-dependent monkeys, dogs and rats with withdrawal symptoms grading standards, combined with the experience of our institute, developed with the drug treatment of morphine-dependent monkey experimental methods and evaluation standards. The standard classifies morphine withdrawal symptoms into four grades, light, medium, heavy and extreme, and scores according to the grade and frequency of withdrawal symptoms. Grading standards for the differential points plus symptoms. At the end of the treatment, the withdrawal symptoms scores and the percent body weight loss for each treatment group were respectively added, and the total average score and the percent body weight loss were calculated. Then between groups t test. In addition, the frequency of withdrawal symptoms of each group of monkeys during the treatment period should be compared with that of the NS group so as to fully understand which of the withdrawal symptoms can be completely inhibited by a certain drug and which can not be controlled or even worsened. The efficacy of the drug depends on the above comprehensive judgment. In this paper, the rule of non-West as an example to illustrate the application of the standard.