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卵巢过度刺激综合征(OHSS)的基本病理生理改变是一种急性毛细血管渗透压的增加。血管内皮生长因子在毛细血管渗出的发生上可能起一定的作用。本文调查了7例严重OHSS的患者,血浆和腹水中血管内皮生长因子水平的变化。研究组7例均进行体外受精(IVF)促排卵,按照Navot等的分类标准显示为严重OHSS,包括卵巢增大,大量腹水(其中4例有胸水)及血液浓缩的表现,如血球压积增高(42.3％±1.1％),白细胞数增高(23 100±2 900/mm~3)和雌二醇(E_2)增加[4 690±540pg/ml(17 217±1 982pmol/L)]。对照组7例为IVF而无OHSS患者,促
The basic pathophysiological alterations of ovarian hyperstimulation syndrome (OHSS) are an increase in acute capillary osmotic pressure. Vascular endothelial growth factor may play a role in the occurrence of capillary leakage. In this study, seven patients with severe OHSS were investigated for changes in plasma and ascites vascular endothelial growth factor levels. In the study group, 7 cases of IVF ovulation induction showed serious OHSS according to the classification criteria of Navot et al. (42.3% +/- 1.1%), increased white blood cell count (23 100 ± 2 900 / mm 3) and increased estradiol (4 690 ± 540 pg / ml 17 217 ± 1 982 pmol / L). Control group, 7 cases of IVF without OHSS patients, and promote