新生儿缺氧缺血性脑病(hypoxie ischaemic eneephalopatby,HIE)是由于围生期的各种因素,导致胎儿或新生儿缺氧和脑血流减少或暂停,从而引起脑损伤,是引起新生儿死亡或幸存患儿永久性神经发育障碍、智能落后的重要原因之一。新生儿缺氧缺血性脑病是新生儿期致残和死亡的最主要的原因之一,在发达国家中的发生率约为3‰,在发展中国家的发生率可能更高〔1〕。本病严重影响了新生儿的健康及 Hypoxic ischemic encephalopathy (HIE) is caused by various factors in the perinatal period, resulting in fetal or neonatal hypoxia and cerebral blood flow decreased or suspended, causing brain damage, is caused by neonatal death Or survival of children with permanent neurodevelopmental disorders, one of the important reasons behind the intelligence. Hypoxic-ischemic encephalopathy (HIE) is one of the major causes of disability and death in the neonatal period, with an incidence of about 3 ‰ in developed countries and a higher incidence in developing countries (1). The disease has a serious impact on the health of the newborn and