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目的研究血管紧张素转换酶抑制剂（ＡＣＥＩ）苯那普利对高血压患者尿微量白蛋白及肾功能的作用。方法４２例高血压患者停用原抗高血压药１周以上，应用苯那普利６周，比较治疗前后血压、微量尿白蛋白、肾素活性改变及肌酐清除率等指标。结果治疗后患者的动脉血压明显降低（Ｐ＜０．００１），尿微量白蛋白减低，肾素活性增高（Ｐ＜０．００１），其他肾功能指标无变化。结论苯那普利在有效降低动脉血压同时具有减少尿微量白蛋白作用，提示对肾有保护作用
Objective To investigate the effect of benazepril, an angiotensin converting enzyme inhibitor (ACEI), on urinary albumin and renal function in patients with hypertension. Methods 42 patients with hypertension were stopped using antihypertensive drugs for more than one week. Benazepril was used for 6 weeks. Blood pressure, urinary albumin, renin activity and creatinine clearance were compared before and after treatment. Results After treatment, the patients’ arterial blood pressure was significantly lower (P <0.001), urinary microalbuminuria and renin activity were increased (P <0.001), while other renal function indexes did not change. Conclusion benazapril in reducing arterial blood pressure at the same time have a role in reducing microalbuminuria, suggesting that the kidney has a protective effect