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研究 μ型阿片受体激动剂羟甲芬太尼 （Ｏｈｍｅｆｅｎｔａｎｙｌ ＯＭＦ）及 δ阿片受体激动剂 Ｄ－Ｓｅｒ－２－Ｌｅｕ－Ｅｎｋｅｐｈａｌｉｎ-Ｔｈｒ （ＤＳＬＥ）对麻醉大鼠心血管和呼吸系统的影响。两药均用微量注射法注入内侧视前区（ｍｅｄｉａｌ ｐｒｅｏｐｔｉｃ ａｒｅａ， ＭＰＯ）。结果：注射 ５ ｎｍｏｌ ＯＭＦ可引起血压下降、心率减慢；注射 １０ ｎｍｏｌ ＯＭＦ引起血压、心率上升；注射δ型阿片受体激动剂 １０ ｎｍｏｌ ＤＳＬＥＴ引起血压下降，但对心率无明显影响。 ２０ ｎｍｏｌ纳洛酮可桔抗ＯＭＦ、ＤＳＬＥＴ的上述效应。上述剂量的ＯＭＦ、ＤＳＬＥＴ均对大鼠呼吸无明显影响。结论：结果提示，内侧视前区注射ＯＭＦ和ＤＳＬＥＴ引起的心血管效应是由阿片受体介导的，ＯＭＦ低剂量降压，高剂量升压；ＤＳＬＥＴ降压。
To investigate the effects of μ-opioid receptor agonist Ohmefentanyl OMF and delta opioid receptor agonist D-Ser-2-Leu-Enkephalin-Thr (DSLE) on cardiovascular and respiratory system in anesthetized rats. Both drugs were injected into the medial preoptic area (MPO) by microinjection. Results: Injecting 5 nmol OMF caused a decrease in blood pressure and heart rate. The injection of 10 nmol OMF caused an increase in blood pressure and heart rate. The injection of 10 nmol DSLET, a δ-opioid receptor agonist, caused a decrease in blood pressure but had no significant effect on heart rate. 20 nmol Naloxone can counteract the above effects of OMF and DSLET. The above doses of OMF, DSLET have no significant effect on rat breathing. CONCLUSIONS: The results suggest that cardiovascular effects induced by OMF and DSLET in the medial preoptic area are opioid receptor-mediated, OMF low-dose, high-dose, and DSLET.