中毒性休克综合征(toxic shock syndrome,TSS)是一种以发热、低血压、皮疹、皮肤脱屑和多器官系统功能损害为特征的临床症候群,1978年由 Todd 等首次描述并命名。近数年来,国外围绕该综合征进行有关研究的报告甚多,发病率亦有逐年上升的趋势,迄止1981年底,报道的确诊病例数已逾1,500例。本文综述国外文献,就 TSS 的病因、发病机理及临床学等诸方面的问题作一介绍,旨在引起国内医务工作者的重视。病因与易患因素现已查明,TSS 的病原体是血浆凝固酶阳性的化 Toxic shock syndrome (TSS) is a clinical syndrome characterized by fever, hypotension, rash, skin desquamation and multiple organ system dysfunction, first described and named by Todd et al. In 1978. In recent years, there have been a lot of reports on the related research around the syndrome in the world. The incidence has also been increasing year by year. By the end of 1981, over 1,500 cases had been reported. This review summarizes the foreign literature and introduces some issues such as the etiology, pathogenesis and clinical aspects of TSS so as to arouse the attention of domestic medical workers. Etiology and predisposing factors have now been identified, and the pathogens of TSS are plasma coagulase-positive