应用吡喹酮缓释片治疗230例日本血吸虫病患者,並以吡喹酮普通片236例作对照,按双盲法进行,剂量40mg/kg1次顿服。缓释片的无反应率31.74％,普通片17.7％。两者差异非常显著(p<0.01)。主要副反应头昏、腹痛、恶心,头痛等也以缓释片发生率明显为少,反应程度也轻,治后3个月粪孵阴转率两种剂型无差异(p>0.05)。认为吡喹酮缓释片40mg/kg1次顿服,值得现场推广。 Application of praziquantel sustained-release tablets in the treatment of 230 cases of schistosomiasis japonica patients, and 236 cases of praziquantel tablets as a control, double-blind method, the dose of 40mg / kg1 Dayton clothing. Non-response rate of sustained-release tablets 31.74%, 17.7% of ordinary tablets. The difference between the two was significant (p <0.01). The main side effects of dizziness, abdominal pain, nausea, headache and other sustained-release tablets were significantly less, the reaction rate is also light, 3 months after treatment of feces and hatching negative conversion rate of the two dosage forms no difference (p> 0.05). Praziquantel sustained release tablets 40mg / kg1 Dayton clothing, it is worth promoting the scene.