论文部分内容阅读
[目的]探讨大剂量托瑞米芬(480mg/d)加长春瑞滨和顺铂(NP方案)联合化疗的毒性反应。[方法]48例晚期非小细胞肺癌(NSCLC)患者随机分为两组。治疗组采用大剂量托瑞米芬+NP方案。对照组仅用NP方案治疗。每次化疗前后记录临床症状、体征,心电图,抽血化验肝、肾功能、电解质、血常规等。化疗2个周期后评价毒副反应。[结果]两组药物毒副反应较轻,主要是骨髓抑制和消化道反应。轻度肝功能损害14例,占29.2%。轻度肾功能损害1例,占2.1%。静脉炎4例,占8.3%。心脏毒性反应5例,占10.4%。无治疗相关性死亡,两组药物毒副反应无显著性差异。[结论]大剂量托瑞米芬联合NP方案治疗NSCLC安全有效,毒副作用可以耐受。
[Objective] To investigate the toxic reaction of high dose toremifene (480mg / d) combined with vinorelbine and cisplatin (NP regimen) in combination with chemotherapy. [Method] Forty-eight patients with advanced non-small cell lung cancer (NSCLC) were randomly divided into two groups. The treatment group with high dose toremifene + NP program. The control group only treated with NP regimen. Before and after each chemotherapy record of clinical symptoms, signs, electrocardiogram, blood tests liver, kidney function, electrolytes, blood and so on. Evaluation of toxicity after 2 cycles of chemotherapy. [Results] The two groups of drugs had less toxic side effects, mainly bone marrow suppression and digestive tract reaction. 14 cases of mild liver damage, accounting for 29.2%. 1 case of mild renal damage, accounting for 2.1%. 4 cases of phlebitis, accounting for 8.3%. Cardiac toxic reactions in 5 cases, accounting for 10.4%. No treatment-related deaths, two groups of drug toxicity was no significant difference. [Conclusion] High-dose toremifene combined with NP regimen is safe and effective in the treatment of NSCLC, and the toxic side effects can be tolerated.