甲氰咪胺是治疗消化性溃疡的有效药物,在早期临床试用时除男子有女性型乳房外几乎未发现有严重副作用,但在早期的毒理学研究表明,在大鼠及狗可引起前列腺及精囊重量减轻,近来研究也证实是如此。本文研究甲氰咪胺作为雄激素拮抗剂对男性下丘脑-垂体-性腺(HPG)轴的作用。7例具有生育能力的男性,平均年龄39.6±3.6岁,因下列原因应用甲氰咪胺:十二指肠溃疡1例,有严重症状的胃十二指肠炎4例,有症状的返流性食 Cimetidine is an effective drug for the treatment of peptic ulcer. In the early clinical trials, almost no serious side effects were observed except for the male breast. However, early toxicological studies showed that rats and dogs can cause prostate and / Seminal vesicle weight loss, recent studies have also confirmed this. This article investigates the effects of cimetidine as an androgen antagonist on the hypothalamic-pituitary-gonadal (HPG) axis in men. Seven men with fertility had an average age of 39.6 ± 3.6 years, with cimetidine applied for the following reasons: 1 case of duodenal ulcer, 4 cases of gastroduodenitis with severe symptoms, and 3 cases of symptomatic regurgitation food