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目的探讨骨成纤维性纤维瘤（ＤＦ）的临床病理特点、组织发生、临床误诊及复发因素。方法收集１１例骨成纤维性纤维瘤病例，男６例，女５例，年龄１１－４２岁。免疫组织化学ＡＢＣ法标记ＳＭａｃｔｉｎ，Ｄｅｓｍｉｎ，Ｖｉｍｅｎｔｉｎ，ＮＳＥ，Ｓ－１００蛋白，ａ－ＡＴ（ａ－平滑肌肌动蛋白）及Ｌｙｓｏｚｇｍｅ。结果Ｖｉ－ｍｅｎｔｉｎ阳性１１例，Ｄｅｓｍｉｎ阳性９例、弱阳性２例，ＳＭａｃｔｉｎ阳性１０例、弱阳性１例，ＮＳＥ、Ｓ－１００蛋白、ａ－ＡＴ及Ｌｙｓｏａｇｍｏ均阴性。３例复发，４例病理性骨折，１１例术前无一例诊断ＤＦ。结论ＤＦ含肌纤维母细胞，此种细胞在组织学上具有平滑肌和纤维母细胞特征。造成临床误诊与复发的主要原因是缺乏特征性的临床表现及Ｘ线表现，肿瘤无包膜。作者发现瘤细胞具有沿骨小梁及哈佛管侵袭性生长的生物学行为，与肿瘤复发有直接相关性。
Objective To investigate the clinicopathological features, histogenesis, misdiagnosis and recurrence factors of bone fibrofibroma (DF). Methods 11 cases of bone fibroblastoma were collected. There were 6 males and 5 females, aged 11-42 years old. Immunohistochemistry ABC method labeled SMactin, Desmin, Vimentin, NSE, S-100 protein, a-AT (a-smooth muscle actin) and Lysozgme. Results Vi-mentin positive in 11 cases, Desmin positive in 9 cases, weakly positive in 2 cases, SMactin positive in 10 cases, weakly positive in 1 case, NSE, S-100 protein, a-AT and Lysoagmo were negative. Three patients had recurrence, 4 had pathological fractures, and 11 patients had no DF before surgery. Conclusion DF contains myofibroblasts, which are histologically characterized by smooth muscle and fibroblasts. The main cause of clinical misdiagnosis and recurrence is the lack of characteristic clinical manifestations and X-ray findings, and the tumor has no capsule. The authors found that tumor cells have biological behavior along the invasive growth of trabeculae and Harvard’s tubules and are directly related to tumor recurrence.