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目的了解石家庄市健康人群乙肝表面抗原(HBs Ag)与乙肝表面抗体(抗-HBs)水平,探讨影响人群抗-HBs的因素。方法对0~,1~,5~,10~,20~,30~,40~59岁组人群进行HBs Ag、抗-HBs检测,并探讨影响人群抗-HBs的因素。结果石家庄市人群HBsAg阳性率、抗-HBs阳性率分别为2.43%和64.78%,人群抗-HBs阳性率具有年龄别差异(x~2=104.674,P<0.001),其中0~组最高为93.29%;男性(70.33%)高于女性(60.22%)(x~2=12.747,P<0.001)。不同免疫规划阶段人群抗-HBs阳性率也有差异(x~2=40.227,P<0.01)。乙肝疫苗首针是否及时接种、是否全程免疫以及最后一针乙肝疫苗免疫时间是影响抗-HBs的重要因素(x~2=166.871,P<0.001、x~2=19.668 P<0.001、x~2=64.180,P<0.001)。结论石家庄市乙肝防控工作取得了良好效果,应进一步提高乙肝疫苗首针及时率和全程接种率,并适时进行乙肝疫苗加强免疫。
Objective To understand the levels of hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (anti-HBs) in healthy population in Shijiazhuang and to explore the factors influencing anti-HBs in the population. Methods HBsAg and anti-HBs were detected in 0 ~, 1 ~, 5 ~, 10 ~, 20 ~, 30 ~, 40 ~ 59 age groups and to explore the factors influencing anti-HBs in the population. Results The positive rates of HBsAg and anti-HBs in population of Shijiazhuang were 2.43% and 64.78%, respectively. The positive rate of anti-HBs in population was age-matched (x ~ 2 = 104.674, P <0.001) %; Male (70.33%) was higher than female (60.22%) (x ~ 2 = 12.747, P <0.001). The anti-HBs positive rate in different immunization planning stages was also different (x ~ 2 = 40.227, P <0.01). Whether the first dose of hepatitis B vaccine is inoculated in time and whether the whole course of immunization and the last dose of hepatitis B vaccine are important factors influencing anti-HBs (x2 = 166.871, P <0.001, x2 = 19.668 P <0.001, = 64.180, P <0.001). Conclusion Hepatitis B prevention and control work in Shijiazhuang has achieved good results. Hepatitis B vaccine should be further improved the first-in-time rate and the whole vaccination rate, and timely hepatitis B vaccine to strengthen immunity.