多发性内分泌自身免疫综合征(polyendocrine autoimmune syndrome,又称polyglandular autoimmune syndrome,PGA)系指病理性自身免疫反应引起两个以上内分泌腺疾病组合的症候群。1904年,Ehrlich首先发现临床上有多个内分泌腺功能减退并存的病例。1926年,Schmidt报道了一组特发性阿狄森氏病(Addison’ss disease,AD)合并慢性淋巴细胞性甲状腺炎(chronic lymphocytic thyroiditis,CLT)的病例,从而肯定了多内分泌腺功能减退共存的关系。嗣后,许多作者相继报道了各种组合 Polyendocrine autoimmune syndrome (polyglandular autoimmune syndrome, polyglandular autoimmune syndrome, PGA) is a syndrome of pathological autoimmune reactions that cause a combination of two or more endocrine disorders. In 1904, Ehrlich first found that there are multiple cases of clinical coexistence of endocrine dysfunction. In 1926, Schmidt reported a cohort of cases of idiopathic Addison’s disease (AD) with chronic lymphocytic thyroiditis (CLT), confirming the coexistence of multiple endocrine dysfunction Relationship. Subsequently, many authors have reported various combinations one after another