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目的:观察高氧液治疗新生儿缺氧缺血性脑病(HIE)的疗效。方法:将90例HIE患儿随机分为观察组50例和对照组40例,观察组在常规治疗的基础上加用高氧液静脉滴注治疗,对照组仅给予常规治疗,观察两组患儿主要症状和体征的改善情况及血氧饱和度变化并进行疗效比较。结果:观察组总有效率为94.0%,对照组总有效率为72.5%,两组比较差异有统计学意义(P<0.01)。两组在液体输注前血气结果差异无统计学意义(P>0.05),观察组在输注高氧液后30 min、60min的血氧饱和度较输注前均有明显变化,同时与对照组相同时段比较,差异均有统计学意义(P<0.01)。两组在改善青紫苍白、呼吸困难、惊厥、血电解质异常等方面比较差异均有统计学意义(P<0.01)。结论:高氧液治疗新生儿HIE安全有效,并能缩短住院天数,明显降低致残率和病死率。
Objective: To observe the effect of hyperoxia liquid on neonatal hypoxic-ischemic encephalopathy (HIE). Methods: Ninety children with HIE were randomly divided into observation group (n = 50) and control group (n = 40). The observation group was treated with intravenous infusion of hyperoxic liquid on the basis of conventional treatment. The control group was given routine treatment only. Children’s main symptoms and signs of improvement and changes in oxygen saturation and the efficacy of comparison. Results: The total effective rate was 94.0% in the observation group and 72.5% in the control group. The difference between the two groups was statistically significant (P <0.01). There was no significant difference in blood gas between the two groups before fluid infusion (P> 0.05). The oxygen saturation of the observation group at 30 min and 60 min after infusion of hyperoxic liquid significantly changed compared with that before the infusion, The same time period, the differences were statistically significant (P <0.01). There was significant difference between the two groups in improving pale paleness, dyspnea, convulsion, blood electrolyte abnormalities (P <0.01). Conclusion: Hyperoxia solution is safe and effective in neonatal HIE and can shorten the length of stay and significantly reduce morbidity and mortality.