抗肿瘤药物的研究已有40年历史。在这期间,人们筛选了近50万个化合物,选出了100多个药物用于临床试验和治疗。应用化学药物治疗肿瘤(所谓“肿瘤的化学治疗”),已成为肿瘤治疗中常用的主要方法之一,并取得了一定的成绩,降低了10余种癌瘤的死亡率。但是,现用的抗肿瘤药物大多数是细胞性毒物,在临床使用时经常产生毒副反应,给患者带来痛苦,甚至迫使患者停药。为弥补这一缺陷,近年来开展了“有效的肿瘤化学治疗”(effective cancer chemo-therapy)研究,此中包括有:选择性抗肿瘤药物的寻求,联合化疗的设计,给药途径的探究,剂型的改进 Anti-cancer drug research has been 40 years old. During this period, nearly 500,000 compounds were screened and over 100 drugs were selected for clinical trials and treatment. The use of chemical drugs in the treatment of tumors (the so-called “chemotherapy of tumors”) has become one of the main methods commonly used in the treatment of cancer and has achieved certain results, reducing the mortality of more than 10 kinds of cancer. However, most of the currently used antitumor drugs are cytotoxic agents, which often cause side effects when used clinically, causing pain to the patient and even forcing the patient to stop taking the drug. In order to remedy this defect, “effective cancer chemo-therapy” studies have been conducted in recent years, including the search for selective anti-cancer drugs, the design of combination chemotherapy, the route of administration Explore, improve the dosage form