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目的:观察益气化痰解毒汤剂联合GP化疗方案对晚期非小细胞肺癌患者免疫功能、生存质量及疗效的影响。方法:将90例气阴两虚兼有痰瘀型晚期非小细胞肺癌患者随机分为观察组与对照组45例。观察组采用益气化痰解毒汤剂联合GP化疗方案治疗,对照组仅采用GP化疗方案治疗。2组均以21天为1疗程,连续治疗2疗程。比较2组患者治疗前后免疫功能指标、KPS评分的变化,治疗后的疗效及毒副反应发生情况。结果:观察组总有效率62.22%,对照组总有效率35.56%,2组比较,差异有统计学意义(P<0.05)。治疗后,观察组CD3~+、CD4~+、CD4~+/CD8~+及自然杀伤(NK)细胞含量均较治疗前增加(P<0.05),而CD8~+含量下降(P<0.05);观察组CD3~+、CD4~+、CD4~+/CD8~+及NK细胞含量均高于对照组(P<0.05),而CD8~+含量低于对照组(P<0.05)。治疗后,2组KPS评分均较治疗前增加(P<0.05);观察组KPS评分高于对照组(P<0.05)。观察组白细胞减少、血小板减少、周围神经毒性、腹泻、恶心呕吐发生率均低于对照组(P<0.05)。结论:益气化痰解毒汤联合GP化疗方案可提高晚期非小细胞肺癌患者的免疫功能,提高生存质量,疗效显著。
Objective: To observe the effect of Yiqi Huatan Jiedu Decoction combined with GP chemotherapy on immune function, quality of life and therapeutic effect in patients with advanced non-small cell lung cancer. Methods: Ninety cases of advanced non-small cell lung cancer with phlegm and blood stasis were randomly divided into observation group (45 cases) and control group (90 cases). The observation group was treated with Yiqi Huatan Jiedu Decoction combined with GP chemotherapy and the control group only with GP chemotherapy. 2 groups were 21 days for a course of treatment, continuous treatment 2 courses. Before and after treatment, immune function indexes, changes of KPS score, therapeutic effect and side effects were compared between the two groups. Results: The total effective rate was 62.22% in the observation group and 35.56% in the control group. There was significant difference between the two groups (P <0.05). After treatment, the levels of CD3 ~ +, CD4 ~ +, CD4 ~ + / CD8 ~ + and NK cells in the observation group increased compared with that before treatment (P <0.05) ; The content of CD3 ~ +, CD4 ~ +, CD4 ~ + / CD8 ~ + and NK cells in the observation group were higher than those in the control group (P <0.05), while the content of CD8 ~ + in the observation group was lower than that of the control group (P <0.05). After treatment, the scores of KPS in both groups increased compared with those before treatment (P <0.05). The scores of KPS in observation group were higher than those in control group (P <0.05). The incidence of leukopenia, thrombocytopenia, peripheral neurotoxicity, diarrhea and nausea and vomiting in the observation group were lower than those in the control group (P <0.05). Conclusion: Yiqi Huatan Jiedu Decoction combined with GP chemotherapy can improve the immune function, improve the quality of life in patients with advanced non-small cell lung cancer and has a significant curative effect.