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目的：探讨不育男子致病原因为雄激素抵抗的可能性。方法：２０７例染色体核型正常的不育男子，按精子计数的高低分为四组：１组（ｎ＝５６）精子计数＜１０×１０６／ｍｌ，２组（ｎ＝５２）精子计数（１０～２０）×１０６／ｍｌ，３组（ｎ＝４８）精子计数（＞２０～４０）×１０６／ｍｌ，４组（ｎ＝５１）精子计数＞４０×１０６／ｍｌ。每例患者均测定血清ＬＨ和Ｔ基础水平，计算ＬＨ×Ｔ乘积（雄激素抵抗指数）。结果：各组的血清ＬＨ和Ｔ基础水平随精子水平的减低而增高，除１组和２组的ＬＨ水平差异不显著外，其余各组ＬＨ和Ｔ水平以及雄激素抵抗指数的组间比较均有显著差异（Ｐ均＜０．０１）。结论：雄激素抵抗是少精子症，特别是严重少精子症或无精子症的致病原因之一。
Objective: To investigate the possibility that male infertility causes androgen resistance. Methods: A total of 207 infertile men with normal karyotype were divided into four groups according to the sperm counts: sperm count (10), sperm count (10) ~ 20) × 106 / ml, sperm count (> 20 ~ 40) × 106 / ml in 3 groups (n = 48) and sperm count> 40 × 106 / ml in 4 groups (n = 51) Serum LH and T basal levels were measured in each patient and the LH × T product (androgen resistance index) was calculated. Results: The levels of serum LH and T in each group increased with the decrease of sperm concentration. Except for the difference of LH level between groups 1 and 2, there was no significant difference between LH and T levels and androgen resistance index There was significant difference (P <0.01). Conclusion: Androgen resistance is one of the causes of oligospermia, especially severe oligozoospermia or azoospermia.