疟疾抗药性的定义是:“任何服用和吸收常用剂量或病人能耐受的较大剂量的抗疟药,疟原虫株仍存活或繁殖的能力”。这个定义可以扩展到各种疟原虫及杀灭血内或组织内的裂殖体、配子体和子孢子等药物的有效剂量,但实际上最普遍地用于恶性疟原虫对血内裂殖体杀灭剂特别是对4—氨基喹啉类的抗性,其他种类的人体疟原虫对这些化合物产生抗性尚无肯定的报告。 Malaria resistance is defined as “the ability of any malaria parasite strain to survive or reproduce, at any higher dose of the anti-malarial drug taken and absorbed at a commonly used dose or tolerated by the patient.” This definition extends to the effective dose of various Plasmodium species and drugs such as schizonts, gametosides and sporozoites that kill blood or tissue, but in fact is most commonly used to kill episodes of schistosome infection by Plasmodium falciparum Agents, especially 4-aminoquinolines, and other types of human Plasmodium which are resistant to these compounds have not been reported with certainty.